Inhibition of primary AML colony growth. (A) Summary of percent inhibition of colony growth of primary marrow mononuclear cells from AML patients treated with AZD1208 or cytarabine. Data shown are from cells continuously treated for 14 days with 3 μM AZD1208 or 30 nM cytarabine. AraC, cytarabine; nd, not determined. (B) Result of colony growth inhibition in Flt3 wild-type (WT or wt) and Flt3-ITD patient samples treated with vehicle control or 0.1, 0.3, 1, or 3 μM AZD1208 in a 14-day methylcellulose assay.