Lymphocytes and lymph node size from baseline to end of treatment. (A) The total absolute lymphocyte count was compared from day 1 prior to the first dose of otlertuzumab to the end of treatment visit which occurred 1 to 2 weeks after the last dose of otlertuzumab. A decrease of greater than 50% was observed at most dose levels and was present overall in 75.5% of patients with an elevated lymphocyte count at day 1. Patients who received otlertuzumab weekly for 4 weeks are included in this graph. (B) Lymph node sum of product diameters from CT scans obtained during screening were compared with CT scans at the end of treatment. A reduction of 50% or greater was observed at 6 mg/kg and higher. Patients who received otlertuzumab weekly for 4 weeks are included in this graph.