Ligand-independent (“tonic”) and ligand-dependent (“chronic”) BCR signaling play a pivotal role in CLL survival and growth. MiRNA-150 dampens the threshold for BCR signaling by repressing expression levels of GAB1 and FOXP1. Professional illustration by Debra T. Dartez.

Ligand-independent (“tonic”) and ligand-dependent (“chronic”) BCR signaling play a pivotal role in CLL survival and growth. MiRNA-150 dampens the threshold for BCR signaling by repressing expression levels of GAB1 and FOXP1. Professional illustration by Debra T. Dartez.

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