Clonogenic capacity of U937 cells transfected with ELANE vectors. Cells transfected with c.1A>G, ATG2 ORF, and ATG 3 ORF all formed significantly fewer clones. A total of 384 wells were counted for each group during each experiment. Data shown are mean ± standard deviation of 3 independent experiments. *P < .05 vs WT; **P < .005 vs WT; ^†P = .05 vs c.1A>G.