Location of downstream in-frame ATG codons in ELANE mRNA and IRES structure. (A) Schematic of ELANE mRNA. In-frame downstream ATG codons that may be used as initiation start sites (asterisks). (B) Potential ELANE IRES showing complementarity to 18S rRNA. Nucleotide substitutions introduced by p.V16M, p.S17F, and p.L18P mutations are marked.