![Figure 1. PVM infection in the cytokine-driven B6-E2IL5tg mouse model of airway inflammation. (A) Total eosinophils in BAL fluid from PVM-infected C57BL/6 (B6) wild-type, B6-eotaxin-2/IL-5 double transgenic (B6-E2IL5tg), eosinophil-deficient B6-ΔdblGATA, and cytokine-enriched eosinophil-deficient B6-E2IL5tg-ΔdblGATA mice; t = 4 days after PVM inoculation; n = 4 to 6 mice per time point; ***P < .0001 (1-way analysis of variance [ANOVA]). (B) Cell differentials of mice described in A. (C-D) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg mice; original magnifications ×10 and ×40, respectively. (E-F) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg-ΔdblGATA mice; original magnifications ×10 and ×40, respectively; area within box in (E) magnified as shown in (F).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/123/5/10.1182_blood-2013-05-502443/4/743f1.jpeg?Expires=1722763129&Signature=Y2YcRpvM4rWweRkCEYl~POTJqv537XniiW6Gl8WYxDPeFTaqkT0AMKKvBsTfg5qk4sAMACInyBDOrUHz-V5JS1RVZizgtX7imZPI0-lL3flkQWA~kqmWmu~kp2DRszgceNCQcHOOb49goN3oEgizXFXszXqUIiFTZf5pYZQLWsvorxmeVNDgK7388bFRoOKliFqilI7tyh4~jruWtA6WjLqhiaoJx85qQz9OoYJGRUQVKad6zJC7wAE1OfzbgXpFrcRt-QIPTEIyS4TSJhK424d1wSMHvsPTIvSZ-XE0DZQLHsHq2ZFBAA83iQ4N7mvBaFCxRdKwoC9GcQ0woVZ28Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PVM infection in the cytokine-driven B6-E2IL5tg mouse model of airway inflammation. (A) Total eosinophils in BAL fluid from PVM-infected C57BL/6 (B6) wild-type, B6-eotaxin-2/IL-5 double transgenic (B6-E2IL5tg), eosinophil-deficient B6-ΔdblGATA, and cytokine-enriched eosinophil-deficient B6-E2IL5tg-ΔdblGATA mice; t = 4 days after PVM inoculation; n = 4 to 6 mice per time point; ***P < .0001 (1-way analysis of variance [ANOVA]). (B) Cell differentials of mice described in A. (C-D) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg mice; original magnifications ×10 and ×40, respectively. (E-F) Microscopic histology of lung tissue from PVM-infected B6-E2IL5tg-ΔdblGATA mice; original magnifications ×10 and ×40, respectively; area within box in (E) magnified as shown in (F).
