High-resolution solution structure of VWF TIL′E′. Ribbon diagram of the lowest-energy solution structure of TIL′E′ of VWF; disulfide bonds are colored yellow. The TIL′ domain (bottom) is shown in blue, and the E′ domain (top) is shown in red. The view of the structure shown to the right is a 90° rotation of the left view. β strands are numbered according to the order in which they occur in the primary sequence of the individual domains (Figure 1). Cysteine linkages are annotated with their residue numbers; a correlation with cysteine numbering within each of the 2 domains can be found in Figure 1.