C1013G/CXCR4-mutated cells differ from the control cells at gene level. (A) GSEA enrichment plots of tumor invasiveness, cell proliferation, antiapoptosis, and oncogenic signature genes in C1013G/CXCR4-mutated cells vs control vector–infected cells (control cells). The green curves show the enrichment score and reflects the degree to which each gene (black vertical lines) is represented at the top or bottom of the ranked gene list. The heat map indicates the relative abundance (red to blue) of the genes specifically enriched in the mutated cells as compared with the control cells. All the gene sets were enriched in C1013G/CXCR4-mutated cells, with an FDR always <0.25. Normalized enrichments score (NES) and FDR are shown per each gene set analyzed. (B) Upregulation of genes in WM patients harboring the C1013G/CXCR4 mutation (n = 10) compared with CXCR4/wild-type WM patients (n = 30). P indicates P value. (C) GSEA enrichment plot for the upregulated genes listed in panel B, in C1013G/CXCR4-mutated cells vs control vector–infected cells (control cells). The same genes were enriched in mutated cells as compared with control cells.