Frequency, types, and treatments of bleeding events. (A) The distribution of 232 spontaneous bleeding events is shown by bars according to different sites and, inside each bar, according to different VWD types. (B) The amount of DDAVP (expressed in median microgram per patient per year) used to treat spontaneous bleeding events in VWD1 (n = 18), VWD2A (n = 8), and VWD2M (n = 12) is shown according to different BS. (C) The amount of VWF/FVIII concentrates (expressed in median VWF:RCo IU per 1000 per patient per year) used to treat spontaneous bleeding events in VWD1 (n = 6), VWD2A (n = 10), VWD2B (n = 5), VWD2M (n = 7), and VWD3 (n = 25) is shown according to different BS.