Expression of S10A mutant confers minor effect on time-to-tumor onset of LMP2A/λ-MYC mice and has no effect on the p53 pathway. (A) Kaplan-Meier curves indicating the percent survival of indicated genotypes. (B) Viability of primary tumor cells (7-AAD^–, CD19⁺) at 3 hours after 5 μM or 10 μM Nutlin-3 treatments from 3 independent experiments. Percentage of viability in vehicle control in each genotype was set at 100%. (C) Western blot analyses of representative primary tumor cells showed aberrant stabilization of p53 and/or p19^ARF in tumors from λ-MYC mice. (D) Hematoxylin and eosin (H&E) staining of tumor-bearing lymph nodes demonstrating a “starry sky” appearance in all tumor genotypes (original magnification ×20).