Model for the altered molecular pathways in myeloid progenitor cells of patients suffering from SCN, in which known genetic mutations lead to decreased SLPI expression and subsequently to altered cell signaling and transcription-factor expression, resulting in abrogated G-CSF–induced granulopoiesis. Arrows indicate confirmed (solid) or speculative (dashed) molecular interactions. IκB, inhibitor of NF-κB; Mut, mutated; ph, phosphorylated. See Figure 7 in the article by Klimenkova et al, which begins on page 1239.