Figure 7
![Figure 7. Enhanced Siglec-G interaction with the CD24 fusion protein mitigates GVHD in WT but not Siglec-G−/− mice. (A-B) Survival. [WT-B6→B6Ly5.2] and [Siglec-G−/−→B6 Ly5.2] chimeras were lethally irradiated with 9 Gy and infused with 2.5 × 106 CD90+ T cells along with 5 × 106 TCD-BM cells from either syngeneic B6 or allogeneic MHC-mismatched BALB/c donors. The recipients were injected with the CD24 Fc protein on day −1 (5 mg/kg) or diluent control on day −1 before allo-HCT (n = 5 to 17 per group, pooled from 2 experiments). For ▲ vs △, P = .001. (B). The bar shows the mean ± SEM.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/123/22/10.1182_blood-2013-12-545335/4/3512f7.jpeg?Expires=1722746788&Signature=jYdgkZnljNDiXiNQl4kgPAmKPSbAYP54eIJgGGjx7kJiajqDMLIa~C8amGBj8hJF5reU4HCmNOlteTESNu0B72dx3nkrkNDbFwkPy3J5wnlHgSzeOgUAgU-8crnfd0S-G~WugcJ~rKQTGOk-WK-pAJpYx-m00~z82MglczccoaSedbMVTAxZLdooQmbBZu3PKji-WfAMdO6Ffo-M6RQahCMoqGWPXgam3dxh0ytoKOhVik0h1UkwpK53krwftyUfdxAokYteS9MpH0-fdI~2f8akVDYKEq~yurb~426CbYki~qVsQAFGyx8s2A4j7X-ly2eTBHgz4t1jHgTMKUteUg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Enhanced Siglec-G interaction with the CD24 fusion protein mitigates GVHD in WT but not Siglec-G−/− mice. (A-B) Survival. [WT-B6→B6Ly5.2] and [Siglec-G−/−→B6 Ly5.2] chimeras were lethally irradiated with 9 Gy and infused with 2.5 × 106 CD90+ T cells along with 5 × 106 TCD-BM cells from either syngeneic B6 or allogeneic MHC-mismatched BALB/c donors. The recipients were injected with the CD24 Fc protein on day −1 (5 mg/kg) or diluent control on day −1 before allo-HCT (n = 5 to 17 per group, pooled from 2 experiments). For ▲ vs △, P = .001. (B). The bar shows the mean ± SEM.
