Monocyte repletion after GdCl3 treatment restores TRALI in SCID mice. (A) Time course of rectal temperatures in naive SCID mice (○) or in SCID mice injected with 50 µg 34.1.2s (□) or in GdCl3-treated SCID mice (△) repleted with 3.5 × 105 purified monocytes. (B) Wet:dry lung weight ratios of lungs from GdCl3-treated SCID mice 2 hours after injection with either 50 μg of 34.1.2s (first column) or 2 hours after repletion with 3.5 × 105 purified monocytes and injection with 34.1.2s (second column) compared with those of SCID mice 2 hours after injection with only 34.1.2s (third column). Data in both panels are expressed as means ± SD of the indicated parameters (y-axes) (n = 5 mice in each group). The ★ indicates significance (P < .05) between mouse groups and was determined by using one-way ANOVA.
