Intraperitoneal administration of antileukinate abrogates TRALI in SCID mice. (A) Rectal temperatures and (B) survival time courses of SCID mice either not injected (control, ○) or injected with 50 µg 34.1.2s (□), 1 mg antileukinate (△), or 1 mg antileukinate + 50 µg 34.1.2s (▿). Two hours after injection of the indicated proteins, the mice were euthanized, (C) serum MIP-2 levels were measured, (D) wet:dry lung weight measurements were made, and (E) the percentage of pulmonary neutrophils was measured. Data are expressed as means ± SD of the indicated parameters (y-axes) in A and C-E and as means in panel B (n = 6 to 11 mice in each group). The ★ indicates significance (P < .05) between mouse groups and was determined by using one-way ANOVA. All other comparisons were not significant except for control vs antileukinate and antileukinate + 34.1.2s (E, P < .05).