Monocyte depletion with GdCl₃ treatment abrogates TRALI in SCID mice. Time course of (A) rectal temperatures and (B) survival of SCID mice either not injected (control, ○) or injected with 50 µg 34.1.2s (□), 90 mg/kg GdCl₃ (△), or 90 mg/kg GdCl₃ plus 50 µg 34.1.2s (▿). Two hours after injection of the indicated proteins, the mice were euthanized, (C) serum MIP-2 levels were measured, (D) wet:dry lung weight measurements were made, and (E) the percentage of pulmonary neutrophils was measured. Data are expressed as means ± standard deviation (SD) of the indicated parameters (y-axes) in A and C-E and as means in B (n = 6 to 11 mice in each group). The ★ indicates significance (P < .05) between mouse groups and was determined by using one-way analysis of variance (ANOVA). All other comparisons were not significant except for control vs GdCl₃ + 34.1.2s (C, P < .05), and control vs GdCl₃ and GdCl₃ + 34.1.2s (E, P < .05).