Age distribution and outcome of patients according to TLR/MYD88 mutations. (A) Histogram representing the percentage distribution of patients according to age at diagnosis for TLR/MYD88-mutated (red line) and TLR/MYD88-unmutated (blue line) CLL patients. (B) TTT in Binet stage A and B patients (red line, TLR/MYD88-mutated patients; blue line, TLR/MYD88-unmutated patients). (C) OS (red line, TLR/MYD88-mutated patients; blue line, TLR/MYD88-unmutated patients). (D) Relative survival (red line, TLR/MYD88-mutated patients; blue line, TLR/MYD88 unmutated patients).