Dynamics of cell populations over time for each of the 10 patients, numbered consecutively. Dots are clinical data, and lines represent the best model fit (see Table 1 for parameters). For each patient, 2 graphs are presented. The left graph depicts the total number of blood lymphocytes over time. Note that these numbers do not represent the standard absolute lymphocyte counts, which are typically presented as the number of cells per microliter of blood. Instead, the number of cells per microliter of blood was multiplied by the blood volume of each patient (supplemental Material 1), to provide numbers that are commensurate with the total number of cells in tissue, which are shown in the right graph for each patient. Only 2 of the 3 tissue volumes were large enough to calculate the number of tissue CLL cells (supplemental Material 1): the measurement before treatment and the first measurement during treatment. Note different scales on the y-axes. Note that the measured initial number of cells in blood and the initial number predicted by the fitted model can differ, which is explained further in supplemental Materials 2.