Time-to-event endpoints. (A) TTR, (B) DOR, (C-D) PFS, and (E) OS. TTR, PFS, and OS are measured from the start of therapy, whereas DOR is measured from the start of response. TTR and DOR are composed of responding subjects only; PFS and OS represent ITT analyses. A tick on the curve (┴) denotes a censored time point. OS, overall survival; PFS, progression-free survival.