Survival analysis for patients in clusters 3 and 11. Kaplan-Meier survival curves and multivariate analysis for OS. Multivariate analysis is based on the Cox proportional hazard ratio (HR) model. The included variables in the model are: NPM1^mut vs wild-type NPM1, FLT3^ITD vs no FLT3^ITD, NRAS^mut/KRAS^mut vs wild-type NRAS/KRAS, and high cytogenetic risk vs no high cytogenetic risk. Age and WBC count are used as a continuous variable. (A) Kaplan-Meier curves for cluster 3 vs all patients except cluster 3 patients, cluster 11 vs all patients except cluster 11 patients, and cluster 3 vs cluster 11 patients. (B) Multivariate analysis for cluster 3 patients.