Lymph node response. (A) Best on-treatment percent changes in the SPD of measured lymph nodes in 54 evaluable patients (blue bars). Graph excludes 10 nonevaluable patients (5 patients with LPL/WM who had no measurable lymphadenopathy and 5 patients without a follow-up, on-treatment tumor assessment). (B) Best on-treatment change from baseline in SPD of measured lymph nodes by dosing regimen in 54 evaluable patients. SEM, standard error of the mean; SPD, sum of the products of the perpendicular diameters (of measured lymph nodes).