AMG 330-mediated lysis of AML cell lines is dependent on CD33 expression intensity. (A) CD33 expression intensity (MFI ratio) of AML cell lines OCI-AML3 and MV4-11. (B-C) Preferential killing of MV4-11 cells (CD33^BRIGHT) compared with OCI-AML3 cells (CD33^DIM) using AMG 330 and PBMCs from a HD. In control wells (C, top) MV4-11 cells showed stronger proliferation compared with OCI-AML3. A representative example for an E:T ratio of 1:1 is shown.