Phenotypic correction assessment. (A) Tail clip survival test assessing the phenotypic correction in 2bF8LV-transduced humanized NSGF8KO mice. The tail clipping test was performed at least 4 weeks after transplantation. Mice surviving beyond 24 hours were considered to have achieved phenotypic correction. Untransduced hCB-transplanted and untransplanted NSGF8KO recipients were tested as controls. Data are summarized from 10 trials of xenotransplants. (B) ROTEM analysis. The ROTEM analysis was performed between 6 and 8 weeks after transplantation when human platelet chimerism was 0.4% to 5.5%. Representative TEMograms (thromboelastometry graphs) from untransplanted NSG, untransplanted NSGF8KO, and 2bF8LV-transduced humanized NSGF8KO (with 2% human platelet chimerism) mice are shown. (C) Whole blood CT determined by ROTEM analysis. Untransplanted NSG and NSGF8KO mice were used as controls. Data are summarized from 5 trials of xenotransplants. N/A, not applicable.