Interrelationship between NOTCH1 mutations (mut) and other recurrently mutated genes and fluorescence in situ hybridization abnormalities in CLL (A). The length of the arc corresponds to the frequency of the genetic lesion, whereas the width of the ribbon indicates the frequency of cooccurrence with the second marker. Kaplan-Meier estimates of PFS for patients stratified by treatment arm and NOTCH1 mutation status (B). WT, wild-type. Panels taken and slightly modified from Figures 1B and 2A in the article by Stilgenbauer et al that begins on page 3247.