Kaplan-Meier plot for overall survival of 175 WM patients from time of diagnosis stratified by MYD88 and CXCR4 mutation status. Differences in survival curves based on CXCR4 and MYD88 mutation status were significant (P < .0001), as was the analysis based on MYD88 status alone (P < .0001) by Fleming-Harrington log-rank analysis.