Specific combined loss of cIAPs and XIAP in the myeloid lineage results in chronic inflammation. (A) Image of a c1^LCc2^−/−X^−/− mouse (deficient for cIAP1 only in myeloid cells and deficient for cIAP2 and XIAP in all tissues) and a littermate mouse. (B) Weights of c1^LCc2^−/−X^−/−, c1^fl/flc2^−/−X^−/−, and WT mice. (C) Levels of G-CSF, M-CSF, TNF, and IL-6 in the sera of c1^LCc2^−/−X^−/−, c1^fl/flc2^−/−X^−/−, and WT mice. Each point represents an individual mouse. Mean ± standard error of the mean (SEM) are shown. **P < .01; *P < .05.