RNAs associated with gender. (A) Multicomponent heatmap of RNAs DE by gender. The upper 2 heatmaps are mRNAs higher and lower in men compared with women, respectively. The bottom 2 heatmaps show miRNAs higher and lower in men compared with women, respectively. The vertical red stripe indicates probesets mapping to genes located on the Y chromosome. Odds ratios of (B) enriched GO categories among mRNAs DE by gender and (C) putative targets of miRNAs DE by gender. (D) A network of miRNAs-mRNAs DE by gender. Network was generated as in Figure 3 except the miRNA was predicted to target the mRNA by ≥1 target prediction algorithm contained in mirDip, and the Spearman correlation coefficient between miRNA abundance and mRNA abundance was less than −0.15 (supplemental Table 7).