Differences of exon usage frequencies in genes that were identified. Exon skipping frequencies were based on RNAseq data, averaged and presented as bar graphs. (A) Bars in dark blue represent U2AF1 mutants; dark brown bars represent WT. The order of genes was determined using the average difference between U2AF1 mutant and WT exon skipping frequency. (B) Detailed frequency of exon skipping of all exons screened for PTBP1 (upper panel) and CEP164 (lower panel). Additional mutational information is depicted for both selected genes. CEP164 lower panel contains additional SNP karyotyping data depicting samples that had the CEP164 locus deleted (highlighted in red).