Schema of talin-1 and kindlin-3–dependent αIIbβ3 activation. Talin-1 and kindlin-3 are prerequisite for αIIbβ3 activation via “inside-out” signaling. Talin-1 binds to 2 distinct binding sites in the β3 cytoplasmic tail: a membrane distal region (a proximal NPxY motif) and a MPR of β3, whereas kindlin-3 binds to the membrane-distal NxxY motif of the β3 cytoplasmic tail.

Schema of talin-1 and kindlin-3–dependent αIIbβ3 activation. Talin-1 and kindlin-3 are prerequisite for αIIbβ3 activation via “inside-out” signaling. Talin-1 binds to 2 distinct binding sites in the β3 cytoplasmic tail: a membrane distal region (a proximal NPxY motif) and a MPR of β3, whereas kindlin-3 binds to the membrane-distal NxxY motif of the β3 cytoplasmic tail.

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