Effects of TAM receptors on inflammation. IFN-α induces TAM receptor expression. TAM signaling usurps the IFNAR/STAT1 cassette to inhibit TLR and JAK signaling via SOCS1 and SOCS3. TAM activation induces Twist, which suppresses NF-κB–dependent transcription reducing pro-inflammatory cytokine production. NF-κB inhibits GAS6 and protein S expression. ASK, apoptosis signal-regulating kinase; IFN-α, interferon-α; IRAK, interleukin-1 receptor–associated kinase; IRF, interferon regulatory factor; JAK, Janus kinase; MyD88, myeloid differentiation primary response gene 88; TRAF, TNF receptor–associated factor; TRIF, TIR domain–containing adapter-inducing IFN-β.