TAM-mediated platelet stabilization and leukocyte adhesion. ADP and Gas6 increase expression of α_IIbβ₃ integrin via PI3K/Akt. After binding to fibrinogen, granule secretion is elevated by outside-in signaling. TAM receptor phosphorylation also leads to increased expression of P-selectin, which binds to PSGL-1 on leukocytes, and increased expression of adhesion molecules ICAM-1 and VCAM-1 by endothelial cells, also stimulating sequestration of leukocytes. Gas6 upregulates tissue factor in endothelial cells upon vessel injury (not depicted), leading to activation of the extrinsic coagulation pathway. ADP, adenosine diphosphate; PI3K, phosphatidylinositol 3-kinases; PSGL-1, P-selectin glycoprotein ligand-1.