The structure of the Tyro3/Axl/Mer receptor. (A) The N-terminal starts with 2 Ig-like domains, followed by 2 fibronectin type 3 domains, followed by a single-pass transmembrane domain and a protein tyrosine kinase at the C-terminal. (B) The structure of the TAM ligands protein S and Gas6. The N-terminal contains a GLA domain, followed by a thrombin-sensitive region (TSR), followed by 4 EGF-like domains, followed by a C-terminal (SHBG-like domain, consisting of 2 LG repeats. EGF, epidermal growth factor; Ig, immunoglobulin; LG, laminin G; SHBG, sex hormone–binding globulin.