Integrated “omic” analysis reveals global metabolic changes. Kyoto Encyclopedia of Genes and Genomes “search&color pathway” analysis for phosphoproteins and metabolites overlaid on the human metabolic reference map (hsa01100). Phosphoproteomic data from one biological replicate of the SU-DHL-1 were used, whereas metabolomic data from 4 averaged biological replicates of SU-DHL-1 cells were used. Metabolites that changed (Student t test, P < .05) in response to CEP treatment were used. Green and red represent decrease and increase, respectively. Lines represent phosphoprotein and dots represent metabolites. Blue shading over glycolysis, TCA cycle, and nucleotide metabolism serve to highlight pathways that are highly represented.