Sorafenib-resistant MOLM-13 cells were more sensitive to HMA. (A) Compared with M13, M13-RE showed an increase in IC₅₀ to sorafenib. (B) No novel ITD and D835Y mutation in M13-RE. Detection of D835Y has been described previously.¹⁶  M13-RE cells also showed (C) higher pH_i, (D) higher sensitivity to HMA in term of growth inhibition, (E) intracellular acidification, and (F) apoptosis.