Effect of TESC knockdown on AML cell lines. (A) TESC was successfully knocked down by siRNA in (i) MOLM-13 and (ii) MV4-11 as shown by western blot. (B) TESC knockdown significantly reduced the growth of (i) MOLM-13 and (ii) MV4-11 6 days posttransfection, accompanied by intracellular acidification and apoptosis induction in MOLM-13 (iii and v) and MV4-11 (iv and vi). n.s., no significant difference as defined by P > .05; SCR, scrambled siRNA; TC, transfection control, no plasmid; TS3, siRNA3; TS4, siRNA4; U, untransfected.