Figure 7
Figure 7. dTMP-GH fusion protein accelerates platelet recovery after ionizing irradiation. BALB/c mice were irradiated with 6.5 Gy TBI and then treated with dTMP-GH (120 μg/kg), dTMP (100 μg/kg), or vehicle once a day for 10 days. Each group contained 20 animals. Three mice from each group were euthanized on day 14, and their tibias were H&E-stained. (A) Peripheral platelet counts. Error bars denote SD. **P < .01 vs control group; #P < .05 vs dTMP group. (B) Duration of thrombocytopenia crisis (platelets <150 × 109/L). **P < .01. (C) Histologic analysis. Blank arrows indicate the mature megakaryocytes near the sinusoid. (D) Survival rates.

dTMP-GH fusion protein accelerates platelet recovery after ionizing irradiation. BALB/c mice were irradiated with 6.5 Gy TBI and then treated with dTMP-GH (120 μg/kg), dTMP (100 μg/kg), or vehicle once a day for 10 days. Each group contained 20 animals. Three mice from each group were euthanized on day 14, and their tibias were H&E-stained. (A) Peripheral platelet counts. Error bars denote SD. **P < .01 vs control group; #P < .05 vs dTMP group. (B) Duration of thrombocytopenia crisis (platelets <150 × 109/L). **P < .01. (C) Histologic analysis. Blank arrows indicate the mature megakaryocytes near the sinusoid. (D) Survival rates.

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