Comparison between TP53 WT and TP53 disrupted cases. (A) Mutual relationship of TP53 disruption with other gene alterations in FR-CLL. In the heat map, rows correspond to identical genes and columns represent individual patients, color-coded based on the gene status (white indicates WT; gray indicates mutations and/or deletion of TP53, mutations and/or deletion of BIRC3, mutations of SF3B1, and mutations of NOTCH1). (B) Percentage of TP53 disrupted and TP53 WT CLL primary cases harboring mutations in the indicated genes.