Plerixafor with imiquimod may improve warts in patients with WHIM syndrome. Images of representative warts that improved during the trial are shown before and after plerixafor treatment of P1 (rows 1 and 2) and P3 (rows 3 and 4). P1 received imiquimod for the final 2 months of the 6-month trial and continued this drug for 1 year after discontinuation of plerixafor. P3 received imiquimod from the start of the trial until 1 year after its conclusion. The patient is designated on the left of each row. “Before Plerixafor” pictures were taken before the start of the trial and “After Plerixafor” pictures were taken at the end of the trial after 6 months of treatment, while “Follow-up off Plerixafor” pictures were taken 9 months and 1 month after treatment with plerixafor for P1 and P3, respectively.