Cartoon depicting the Bcl11b locus in non-T and T cells. (A) In non-T cells, the Bcl11b promoter is often DNA-methylated and does not physically interact with its downstream enhancer, which is marked by H3K27me3. (B) In T cells and committed T-cell precursors, the actively transcribing Bcl11b promoter is unmethylated and interacts with the enhancer, which is marked by H3K4me2 (and H3K4me1) and bound by transcription factors associated with T-cell development such as Pu1, Gata3, and Tcf1 (among others).