Frequency and distribution of mutations in patients with MPN. (A) Number of patients with mutations in the genes is indicated. ET patients are depicted in yellow, PV patients in red, and PMF patients in light brown. Numeric chromosomal aberrations are marked in italic font. (B) Distribution of somatic mutations among the 197 MPN patients according to phenotype. The shades of gray indicate the number of somatic mutations per patient. (C) Average number of somatic mutations per patient in CALR-positive (left panel) and JAK2-V617F–positive individuals (left panel) observed in ET, PV, and PMF patients, respectively. (D) Circos plot illustrating cooccurrence of somatic mutations in the same individual. The length of the arc corresponds to the frequency of the mutation, whereas the width of the ribbon corresponds to the relative frequency of co-occurrence of 2 mutations in the same patient. (E) Circos plot showing cooccurrence of somatic mutations in CALR-positive patients. (F) Circos plot showing co-occurrence of somatic mutations in patients negative for JAK2 V617F and mutations in CALR.