The frequency and the pairwise cooccurrence of mutations in the entire study cohort (n = 166). (A) These are represented by a Circos diagram. Cooccurring mutations are indicated in the clockwise direction; the length of the arc corresponds to the frequency of mutation in the first gene (color coded), and the width of the ribbon corresponds to the frequency of patients who also had a mutation in the second gene. The individual mutated genes for each patients in the whole cohort are indicated in (B).