Activation of the formyl peptide receptor 1 (FPR1) by fMet-Leu-Phe (fMLF), the integrin by pRGD (an Arg-Gly-Asp-containing fibronectin-like binding fragment), and the Fcg receptors (not shown) leads to phospholipase C (PLC) activation, hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), and IP3 production. The resulting release of Ca2+ from ER triggers STIM1-dependent Ca2+ influx, causing sustained increase of intracellular Ca2+ concentration through the opening of the ORAI calcium release-activated calcium modulator, and the transient receptor potential (TRP) channel, TRPC. Ca2+-dependent and diacylglycerol (DAG)-dependent activation of PKCa and PKCb leads to phosphorylation of p47phox (circled P's in the figure) and assembly of a functional NADPH oxidase in neutrophils. FAK, focal adhesion kinase that mediates integrin signaling; p47phox, a cytosolic component of the phagocyte NADPH oxidase (phox) with an apparent molecular weigh of 47 kDa. Professional illustration by Debra T. Dartez.

Activation of the formyl peptide receptor 1 (FPR1) by fMet-Leu-Phe (fMLF), the integrin by pRGD (an Arg-Gly-Asp-containing fibronectin-like binding fragment), and the Fcg receptors (not shown) leads to phospholipase C (PLC) activation, hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), and IP3 production. The resulting release of Ca2+ from ER triggers STIM1-dependent Ca2+ influx, causing sustained increase of intracellular Ca2+ concentration through the opening of the ORAI calcium release-activated calcium modulator, and the transient receptor potential (TRP) channel, TRPC. Ca2+-dependent and diacylglycerol (DAG)-dependent activation of PKCa and PKCb leads to phosphorylation of p47phox (circled P's in the figure) and assembly of a functional NADPH oxidase in neutrophils. FAK, focal adhesion kinase that mediates integrin signaling; p47phox, a cytosolic component of the phagocyte NADPH oxidase (phox) with an apparent molecular weigh of 47 kDa. Professional illustration by Debra T. Dartez.

Close Modal

or Create an Account

Close Modal
Close Modal