Effect of treatment with control, fVII, fXI, fXII, or HK ASOs on the aPTT and dilute PT. Rabbits were treated subcutaneously with control, fVII, fXI, fXII, or HK ASOs for 4 weeks at 15 mg/kg twice weekly (n = 8 per treatment group). Two days after the last ASO dose, blood was collected for determination of the aPTT (black bars) or dilute PT (white bars). Values were normalized relative to those obtained in rabbits given the control ASO. The bars represent the mean of 3 separate determinations for each rabbit, whereas the lines above the bars reflect the SD. *P < .05 compared with control ASO.