Figure 1
![Figure 1. JAK2 is required for initiation of MPLW515L-mediated disease. Deletion of Jak2 following engraftment of MPLW515L-transduced BM leads to significant reduction in (A) WBC counts, (B) platelets, (C) mutant allele burden in terms of GFP-positive cells in PB (P < .005), and (D) spleen (P < .05) and (E) liver size (P < .05) as compared with controls. (F) BM fibrosis assessed by reticulin staining is absent in Jak2-deleted BM. (Data are represented at mean ± standard error of the mean [SEM]; Jak2+/+, n = 4; Jak2−/−, n = 5).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/123/13/10.1182_blood-2014-01-547760/4/2075f1.jpeg?Expires=1722574025&Signature=2upaZRenxJUPi10gXZvD3o-K~-VShisTeTJWooaDPxG-cRKrOr5wvh4koGvcdG1trLmM529MJqR6wRIs663W8Hyk7uk6be6ZirMGlZf2HBv16GXGACn1OjnAOA33V7VioJr1vAI7~oKyilxoFfDa8cijua7cJxvg8Papx-PdtLMjJZMwgnC0cjHNFdm1lhJjFxJs84E6XnIiae8R8z-BAuy-ycHNo1D~TUXWu-hB-Qic51N69p-ez7yPt8T1LX67YrmPxh7LZ-TV9cGD3fPCQ76IloKjihn2AF7QpCHjSCCZmNDSlJLdQq-fU2JWMcG2bEAdz5vQhzE~QVjPviHoYg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
JAK2 is required for initiation of MPLW515L-mediated disease. Deletion of Jak2 following engraftment of MPLW515L-transduced BM leads to significant reduction in (A) WBC counts, (B) platelets, (C) mutant allele burden in terms of GFP-positive cells in PB (P < .005), and (D) spleen (P < .05) and (E) liver size (P < .05) as compared with controls. (F) BM fibrosis assessed by reticulin staining is absent in Jak2-deleted BM. (Data are represented at mean ± standard error of the mean [SEM]; Jak2+/+, n = 4; Jak2−/−, n = 5).
