Altered hemostasis in Ip6k1^−/− mice. (A) Bleeding time was measured following tail tip amputation in WT and Ip6k1^−/− mice. Data are mean ± standard error (n = 11; *P ≤ .05). (B) Scatter plot indicating survival time of WT and Ip6k1^−/− mice challenged with ADP to induce pulmonary thromboembolism. “Control” indicates WT mice injected with sterile water as a vehicle control. Animals that were alive 30 minutes after the challenge were considered survivors. (C) Hematoxylin and eosin–stained sections of lungs of WT and Ip6k1^−/− mice that survived the challenge with ADP. Representative images from 3 different mice of each genotype are shown. Scale bars represent 100 µm.