Model for CCND1 transcription activation proposed by Allinne and colleagues. In the schematic representation of the nucleus, the wild-type CCND1 is indicated in red and the IgH in green, whereas the der(14) corresponding to the translocated IgH-CCND1 allele (fusion of red and green signals) is located in the periphery of a nucleolus (dark blue). The t(11;14) shifts toward the nucleolus. The intact CCND1 allele, transcriptionally inactive, is represented in the upper part of the figure; the translocated CCND1 allele, transcriptionally active, is represented in the lower part. Several regions related with its activation are highlighted: the CCND1-binding sites for CTCF and LR1, the active acetylation marks in the promoter and the nucleolus close proximity, with abundant nucleolin, active PolII clusters and CTCF. Distant Eμ IgH enhancer is also indicated. cen, centromere; tel, telomere.