Results of relapse analyses for all patients stratified by pretransplant CMV serology. (A) Adjusted HR and 95% CI from multivariable models evaluating CMV antigenemia by day 100 as a risk factor for relapse at day 100 and 1 year after HCT among CMV-seropositive patients (CMV R+) and CMV-seronegative patients (CMV R−). Covariates: 1, disease risk (low, standard, or high); 2, patient race (unknown/other or white); 3, donor CMV serostatus (D− vs D+); 4, cell source (bone marrow vs PBSC); 5, patient age (0-40 years or ≥41 years); 6, conditioning regimen (myeloablative vs reduced intensity). (B) Cumulative relapse incidence at 1 year after HCT by CMV antigenemia occurring before day 50 among patients surviving relapse-free to day 50 after HCT.