Brentuximab vedotin extends the survival of PEL xenograft mice. Kaplan-Meier survival curves of PEL xenograft mice. NOD/SCID mice (n = 5/group) were injected with 25 × 10⁶ UM-PEL-1 (A) and UM-PEL-3 (B) cells. At 3 days postinjection, mice were treated for 3 weeks with interperitoneal injections of brentuximab vedotin (B.V.), PBS, or isotype-matched irrelevant Ig-vcMMAE. Only one control group is shown, because mice in both groups exhibited identical Kaplan-Meirer survival curves. Results are representative of 2 independent experiments.