Brentuximab vedotin induces G2/M cell cycle arrest of PEL cells. PEL cell lines BC-1 (A), BC-3 (B), UM-PEL-1c (C), and UM-PEL-3c (D) were treated with brentuximab vedotin (B.V.) at increasing concentrations. At 24 hours after treatment, cells were stained with propidium iodide to measure DNA content and analyzed by flow cytometry for cell cycle distribution. Bar graphs indicate the percentage of cells in different phases of cell cycle (G0, G1, S, G2/M). Experiments depicted in panels A-D were repeated thrice independently in triplicate. The representative data from one experiment are shown. Error bars correspond to standard error of the mean in all graphs.