Incidences and distributions of genetic markers. (A) Incidences of genetic markers for all patients with mutation data of NOTCH1 and SF3B1 available (n = 97). Rows represent genetic markers and columns represent individual patients, color-coded based on the marker status (red: NOTCH1^mut; orange: SF3B1^mut; yellow: TP53^mut; green: 17p deletion; blue: 11q deletion; purple: trisomy 12; dark blue: 13q deletion; gray: IGHV unmutated [UM]). Hatched gray indicates missing data. (B) Circos diagrams illustrating pairwise co-occurrence of gene mutations with genomic aberrations (left) and with IGHV status (right). Circle segments depict the relative frequency of mutations, aberrations, or IGHV status and their co-occurrence. The width of the ribbons corresponds to the proportion of pairwise co-occurring mutations and aberrations or IGHV status. Unoccupied parts of the segments represent cases with only a single mutation or aberration.