Effect of applied treatments on the level of nucleosomes in plasma. (A) Treatment with rhADAMTS13 and its coadministration with DNase I significantly decreased the levels of circulating nucleosomes in plasma 24 hours after MI/R. Nucleosome levels are expressed as a fold increase over the baseline (*P < .05, **P < .01, as compared with vehicle-treated mice). (B) This graph depicts a significant positive association between plasma nucleosome levels and the degree of cardiac damage (infarct size, % of LV) among mice from all experimental groups.